Progressive changes in a recognition memory network in Parkinson's disease
Identifieur interne : 001264 ( Main/Corpus ); précédent : 001263; suivant : 001265Progressive changes in a recognition memory network in Parkinson's disease
Auteurs : Bàrbara Segura ; Naroa Ibarretxe-Bilbao ; Roser Sala-Llonch ; Hugo Cesar Baggio ; María Jose Martí ; Francesc Valldeoriola ; Pere Vendrell ; Nuria Bargall ; Eduard Tolosa ; Carme JunquéSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2013-04.
Abstract
Background In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time. Methods We studied 17 PD patients and 13 age and sex matched healthy subjects. In both groups fMRI (recognition memory paradigm) and neuropsychological assessments were obtained at baseline and at follow-up. To analyse changes over time in functional networks, model free (independent component analysis) analyses of the fMRI data were carried out. Then, a cross correlation approach was used to assess the changes in the strength of functional connectivity. Results At follow-up, patients showed reduced recruitment of one network, including decreased activation in the orbitofrontal cortices, middle frontal gyri, frontal poles, anterior paracingulate cortex, superior parietal lobes and left middle temporal gyrus, as well as decreased deactivation in the anterior paracingulate gyrus and precuneus. Cross correlation analyses over time showed a decrease in the strength of functional connectivity between the middle frontal gyrus and the superior parietal lobe in PD patients. Conclusions Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.
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DOI: 10.1136/jnnp-2012-302822
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de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:283D5F4E54A3E450F99855B57AA9DED34E58FE94</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/jnnp-2012-302822</idno><idno 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Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain</mods:affiliation></affiliation></author><author><name sortKey="Sala Llonch, Roser" sort="Sala Llonch, Roser" uniqKey="Sala Llonch R" first="Roser" last="Sala-Llonch">Roser Sala-Llonch</name><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Baggio, Hugo Cesar" sort="Baggio, Hugo Cesar" uniqKey="Baggio H" first="Hugo Cesar" last="Baggio">Hugo Cesar Baggio</name><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="María Jose" last="Martí">María Jose Martí</name><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Vendrell, Pere" sort="Vendrell, Pere" uniqKey="Vendrell P" first="Pere" last="Vendrell">Pere Vendrell</name><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Bargall, Nuria" sort="Bargall, Nuria" uniqKey="Bargall N" first="Nuria" last="Bargall">Nuria Bargall</name><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Tolosa, Eduard" sort="Tolosa, Eduard" uniqKey="Tolosa E" first="Eduard" last="Tolosa">Eduard Tolosa</name><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-04">2013-04</date><biblScope unit="volume">84</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="370">370</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">283D5F4E54A3E450F99855B57AA9DED34E58FE94</idno><idno type="DOI">10.1136/jnnp-2012-302822</idno><idno type="href">jnnp-84-370.pdf</idno><idno type="ArticleID">jnnp-2012-302822</idno><idno type="PMID">23117490</idno><idno type="local">jnnp;84/4/370</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time. Methods We studied 17 PD patients and 13 age and sex matched healthy subjects. In both groups fMRI (recognition memory paradigm) and neuropsychological assessments were obtained at baseline and at follow-up. To analyse changes over time in functional networks, model free (independent component analysis) analyses of the fMRI data were carried out. Then, a cross correlation approach was used to assess the changes in the strength of functional connectivity. Results At follow-up, patients showed reduced recruitment of one network, including decreased activation in the orbitofrontal cortices, middle frontal gyri, frontal poles, anterior paracingulate cortex, superior parietal lobes and left middle temporal gyrus, as well as decreased deactivation in the anterior paracingulate gyrus and precuneus. Cross correlation analyses over time showed a decrease in the strength of functional connectivity between the middle frontal gyrus and the superior parietal lobe in PD patients. Conclusions Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Bàrbara Segura</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Naroa Ibarretxe-Bilbao</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain</json:string></affiliations></json:item><json:item><name>Roser Sala-Llonch</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Hugo Cesar Baggio</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>María Jose Martí</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Francesc Valldeoriola</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Pere Vendrell</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Nuria Bargalló</name><affiliations><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Eduard Tolosa</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Carme Junqué</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Cognitive neurology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Memory</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's Disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mri</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Neuropsychology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Functional Imaging</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Background In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time. Methods We studied 17 PD patients and 13 age and sex matched healthy subjects. In both groups fMRI (recognition memory paradigm) and neuropsychological assessments were obtained at baseline and at follow-up. To analyse changes over time in functional networks, model free (independent component analysis) analyses of the fMRI data were carried out. Then, a cross correlation approach was used to assess the changes in the strength of functional connectivity. Results At follow-up, patients showed reduced recruitment of one network, including decreased activation in the orbitofrontal cortices, middle frontal gyri, frontal poles, anterior paracingulate cortex, superior parietal lobes and left middle temporal gyrus, as well as decreased deactivation in the anterior paracingulate gyrus and precuneus. Cross correlation analyses over time showed a decrease in the strength of functional connectivity between the middle frontal gyrus and the superior parietal lobe in PD patients. Conclusions Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.</abstract><qualityIndicators><score>9.248</score><pdfVersion>1.6</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1610</abstractCharCount><pdfWordCount>5638</pdfWordCount><pdfCharCount>39582</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>229</abstractWordCount></qualityIndicators><title>Progressive changes in a recognition memory network in Parkinson's disease</title><pmid><json:string>23117490</json:string></pmid><genre><json:string>research-article</json:string></genre><host><volume>84</volume><pages><first>370</first></pages><issn><json:string>0022-3050</json:string></issn><issue>4</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-330X</json:string></eissn><title>Journal of Neurology, 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Ltd</publisher><availability><p>BMJ</p></availability><date>2012-10-31</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Progressive changes in a recognition memory network in Parkinson's disease</title><author><persName><forename type="first">Bàrbara</forename><surname>Segura</surname></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Naroa</forename><surname>Ibarretxe-Bilbao</surname></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain</affiliation></author><author><persName><forename type="first">Roser</forename><surname>Sala-Llonch</surname></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Hugo Cesar</forename><surname>Baggio</surname></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">María Jose</forename><surname>Martí</surname></persName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Francesc</forename><surname>Valldeoriola</surname></persName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Pere</forename><surname>Vendrell</surname></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation></author><author><persName><forename type="first">Nuria</forename><surname>Bargalló</surname></persName><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Eduard</forename><surname>Tolosa</surname></persName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Carme</forename><surname>Junqué</surname></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-04"></date><biblScope unit="volume">84</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="370">370</biblScope></imprint></monogr><idno type="istex">283D5F4E54A3E450F99855B57AA9DED34E58FE94</idno><idno type="DOI">10.1136/jnnp-2012-302822</idno><idno type="href">jnnp-84-370.pdf</idno><idno type="ArticleID">jnnp-2012-302822</idno><idno type="PMID">23117490</idno><idno type="local">jnnp;84/4/370</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2012-10-31</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Background In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time. Methods We studied 17 PD patients and 13 age and sex matched healthy subjects. In both groups fMRI (recognition memory paradigm) and neuropsychological assessments were obtained at baseline and at follow-up. To analyse changes over time in functional networks, model free (independent component analysis) analyses of the fMRI data were carried out. Then, a cross correlation approach was used to assess the changes in the strength of functional connectivity. Results At follow-up, patients showed reduced recruitment of one network, including decreased activation in the orbitofrontal cortices, middle frontal gyri, frontal poles, anterior paracingulate cortex, superior parietal lobes and left middle temporal gyrus, as well as decreased deactivation in the anterior paracingulate gyrus and precuneus. Cross correlation analyses over time showed a decrease in the strength of functional connectivity between the middle frontal gyrus and the superior parietal lobe in PD patients. Conclusions Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Memory</term></item><item><term>Parkinson's Disease</term></item><item><term>Mri</term></item><item><term>Neuropsychology</term></item><item><term>Functional Imaging</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-10-31">Created</change><change when="2013-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/283D5F4E54A3E450F99855B57AA9DED34E58FE94/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-id journal-id-type="publisher-id">jnnp</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><abbrev-journal-title>J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">jnnp-2012-302822</article-id><article-id pub-id-type="doi">10.1136/jnnp-2012-302822</article-id><article-id pub-id-type="other">jnnp;84/4/370</article-id><article-id pub-id-type="other">jnnp;jnnp-2012-302822</article-id><article-id pub-id-type="pmid">23117490</article-id><article-id pub-id-type="other">370</article-id><article-id pub-id-type="other">jnnp-2012-302822</article-id><article-categories><subj-group subj-group-type="heading"><subject>Cognitive neurology</subject></subj-group><series-title>Research paper</series-title></article-categories><title-group><article-title>Progressive changes in a recognition memory network in Parkinson's disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Segura</surname><given-names>Bàrbara</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ibarretxe-Bilbao</surname><given-names>Naroa</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Sala-Llonch</surname><given-names>Roser</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Baggio</surname><given-names>Hugo Cesar</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Martí</surname><given-names>María Jose</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Valldeoriola</surname><given-names>Francesc</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Vendrell</surname><given-names>Pere</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bargalló</surname><given-names>Nuria</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Tolosa</surname><given-names>Eduard</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Junqué</surname><given-names>Carme</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref></contrib></contrib-group><aff id="af1"><label>1</label>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</aff><aff id="af2"><label>2</label>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</aff><aff id="af3"><label>3</label>Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain</aff><aff id="af4"><label>4</label>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</aff><aff id="af5"><label>5</label>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</aff><aff id="af6"><label>6</label>Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</aff><author-notes><corresp><label>Correspondence to</label> Professor C Junque, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Casanova 143, Barcelona 08036, Spain; <email>cjunque@ub.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2013</year></pub-date><pub-date pub-type="epub-original"><day>31</day><month>10</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>31</day><month>10</month><year>2012</year></pub-date><volume>84</volume><volume-id pub-id-type="other">84</volume-id><volume-id pub-id-type="other">84</volume-id><issue>4</issue><issue-id pub-id-type="other">jnnp;84/4</issue-id><issue-id pub-id-type="other">4</issue-id><issue-id pub-id-type="other">84/4</issue-id><fpage>370</fpage><history><date date-type="received"><day>21</day><month>3</month><year>2012</year></date><date date-type="rev-recd"><day>31</day><month>8</month><year>2012</year></date><date date-type="accepted"><day>20</day><month>9</month><year>2012</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-84-370.pdf"></self-uri><abstract><sec><title>Background</title><p>In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time.</p></sec><sec><title>Methods</title><p>We studied 17 PD patients and 13 age and sex matched healthy subjects. In both groups fMRI (recognition memory paradigm) and neuropsychological assessments were obtained at baseline and at follow-up. To analyse changes over time in functional networks, model free (independent component analysis) analyses of the fMRI data were carried out. Then, a cross correlation approach was used to assess the changes in the strength of functional connectivity.</p></sec><sec><title>Results</title><p>At follow-up, patients showed reduced recruitment of one network, including decreased activation in the orbitofrontal cortices, middle frontal gyri, frontal poles, anterior paracingulate cortex, superior parietal lobes and left middle temporal gyrus, as well as decreased deactivation in the anterior paracingulate gyrus and precuneus. Cross correlation analyses over time showed a decrease in the strength of functional connectivity between the middle frontal gyrus and the superior parietal lobe in PD patients.</p></sec><sec><title>Conclusions</title><p>Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.</p></sec></abstract><kwd-group><kwd>Memory</kwd><kwd>Parkinson's Disease</kwd><kwd>Mri</kwd><kwd>Neuropsychology</kwd><kwd>Functional Imaging</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><partName>Research paper</partName><title>Progressive changes in a recognition memory network in Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><partName>Research paper</partName><title>Progressive changes in a recognition memory network in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Bàrbara</namePart><namePart type="family">Segura</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Naroa</namePart><namePart type="family">Ibarretxe-Bilbao</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roser</namePart><namePart type="family">Sala-Llonch</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hugo Cesar</namePart><namePart type="family">Baggio</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">María Jose</namePart><namePart type="family">Martí</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesc</namePart><namePart type="family">Valldeoriola</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pere</namePart><namePart type="family">Vendrell</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nuria</namePart><namePart type="family">Bargalló</namePart><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduard</namePart><namePart type="family">Tolosa</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carme</namePart><namePart type="family">Junqué</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2013-04</dateIssued><dateCreated encoding="w3cdtf">2012-10-31</dateCreated><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Background In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time. Methods We studied 17 PD patients and 13 age and sex matched healthy subjects. In both groups fMRI (recognition memory paradigm) and neuropsychological assessments were obtained at baseline and at follow-up. To analyse changes over time in functional networks, model free (independent component analysis) analyses of the fMRI data were carried out. Then, a cross correlation approach was used to assess the changes in the strength of functional connectivity. Results At follow-up, patients showed reduced recruitment of one network, including decreased activation in the orbitofrontal cortices, middle frontal gyri, frontal poles, anterior paracingulate cortex, superior parietal lobes and left middle temporal gyrus, as well as decreased deactivation in the anterior paracingulate gyrus and precuneus. Cross correlation analyses over time showed a decrease in the strength of functional connectivity between the middle frontal gyrus and the superior parietal lobe in PD patients. Conclusions Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.</abstract><subject><genre>Keywords</genre><topic>Memory</topic><topic>Parkinson's Disease</topic><topic>Mri</topic><topic>Neuropsychology</topic><topic>Functional Imaging</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID">jnnp</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>370</start></extent></part></relatedItem><identifier type="istex">283D5F4E54A3E450F99855B57AA9DED34E58FE94</identifier><identifier type="DOI">10.1136/jnnp-2012-302822</identifier><identifier type="href">jnnp-84-370.pdf</identifier><identifier type="ArticleID">jnnp-2012-302822</identifier><identifier type="PMID">23117490</identifier><identifier type="local">jnnp;84/4/370</identifier><accessCondition type="use and reproduction" contentType="copyright">Published by the BMJ Publishing Group Limited. 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